B cells keep on editing
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چکیده
منابع مشابه
B cells keep on editing
proteins fashioned by swollen cardiomyocytes. The mice and their heart muscle cells also had a higher-than-normal death rate. Loss of Notch also spurred more heart stem cells to differentiate. Notch might allow the heart to conserve these cells. The Notch pathway triggers stem cell proliferation in skeletal muscle, and the pathway shortcircuits as we age. The researchers say that it’s possible ...
متن کاملEditing and escape from editing in anti-DNA B cells.
Tolerance to dsDNA is achieved through editing of Ig receptors that react with dsDNA. Nevertheless, some B cells with anti-dsDNA receptors escape editing and migrate to the spleen. Certain anti-dsDNA B cells that are recovered as hybridomas from the spleens of anti-dsDNA H chain transgenic mice also bind an additional, Golgi-associated antigen. B cells that bind this antigen accumulate intracel...
متن کاملEditing Anti-DNA B Cells by Vλx
Receptor editing is performed by replacement of Vkappa genes that contribute to autoreactivity. In addition, the Ckappa locus can be deleted by Vkappa rearrangement to intronic or 3' of Ckappa RS sequences (also referred to as kappa deletion elements). B cells that delete the Ckappa can then express lambda light chains. However, the lambda locus, either of man or mouse, does not allow V gene re...
متن کاملReceptor editing: How B cells stay tolerant
In 1993, David Nemazee and Martin Weigert independently showed that autoreactive B cells could proofread, alter, and reexpress modified receptors to become nonautoreactive. This process, called "receptor editing," has since gained prominence as the main mechanism of B cell tolerance.
متن کاملReceptor Editing in Se • reactive Bone Marrow B Cells
A central paradigm of immunology is clonal selection: lymphocytes displaying donally distributed antigen receptors are generated and subsequently selected by antigen for growth or elimination. Here we show that in mice transgenic for anti-H-2K k,b antibody genes, in which a homogeneous clone of developing B cells can be analyzed for the outcome of autoantigen encounter, surface immunoglobulin M...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2008
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20513iti5